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Time Series Analysis & Modelling

Apr 26, 2006, 1:15 pm in room 316.

R. Steuer: Structural Kinetic Modeling of Metabolic Networks

Abstract:
To develop and investigate detailed mathematical models of metabolic
processes is one of the
primary challenges in systems biology. However, despite considerable
advance in the topological analysis
of metabolic networks, kinetic modeling based on differential equations
is still
often severely hampered by inadequate knowledge of the enzyme-kinetic
rate laws and their associated parameter values.
Here we propose a method that aims to give a detailed and quantitative
account of
the dynamical capabilities of a metabolic system,  without requiring any
explicit information about the particular
functional form of the rate equations.
Our approach allows to identify crucial reaction steps that
predominantly contribute to the stability,
and thus robustness, of an experimentally observed state and can give
explicit biochemical conditions for which a specific dynamical behavior
can be expected.

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