| Molecular models of diseases kinetics | Brownian Motion of Biomolecules |
Molecular Models of Diseases Kinetics
It is generally
acknowledged that transmittable spongiform encephaloathies diseases (TSE),
such
as scrapie, kuru and kind of Creutzfeld-Jacob
disease are related to formation of misfolded fibril-like
prion proteins. Using a molecular
model of the aggregation kinetics we describe the kinetics of the
prion growth and derived the size
distribution of the fibril aggregates.
My main publications on the topic are:
T.Poeschel, N.V. Brilliantov, and C. Frommel,
Kinetics of Prion Growth,
Biophysical Journal, 85, (2003) 3460-3474.
pdf file
Brownian Motion of Biomolecules
Biological functions of biomolecules
in nature are intrinsically related to their mobility, i.e. to
the properties of the Brownian
motion of these particles. Usually they are strongly charged or
have a large electrical dipolar
moment. The intensive electrostatic interactions between the
charged and/or dipolar biomolecules
or between the macromolecules and the polar solvent
influence significantly their Brownian
Motion .
My main publications on the topic are:
N.V.Brilliantov, N.G.Vostrikova, V.P.Denisov,
Yu.M.Petrusievich and O.P.Revokatov
Influence of dielectric friction and near-surface
increase of viscosity on rotational
Brownian motion of charged
biopolymers in solution,
Biophysical Chemistry, 46 (1993) 227-236.
Yu. M. Petrusevitch and N. V. Brilliantov,
Dielectric properties of protein solutions
and interactionof electromagnetic fields with biosystems.
Bull. Mosc. State Univ., Ser.3, N4 (1994)
63-67 (in russian).
N.V.Brilliantov, A.I.Kviatkievich, Yu.M.Petrusievich
and O.P. Revokatov,
Influence of macromolecules
dipolar moment on the frequency dependence of
the NMR-relaxation coefficients of
biopolymers in solution.
Radiospektroskopiya, Perm, 1988,150-154 (in
russian).
N.V.Brilliantov, A.I.Kviatkievich, Yu.M.Petrusievich
and O.P.Revokatov,
Rotational Brownian motion of polar
macromolecules in solutions,
Dokl. Akad. Sci. USSR, 304,
N2 (1989) 340-345 (in russian).